CREB-TF (CREB is cAMP response element-binding protein) can be described as a cellular transcription factor. It binds with certain DNA sequences known as cAMP response element-binding protein. Genes whose transcription is regulated by CREB include c-fos, BDNF, tyrosine hydroxylase, numerous neuropeptides, and genes involved in the mammalian circadian clock (PER1, PER2).
The role of CREB in neuronal plasticity, long-term memory formation, and neuronal plasticity is well-known. CREB, a bZIP transcription element that activates target genes via cAMP response elements, is known as CREB. CREB can mediate many physiological stimuli and regulate a wide range of cellular responses. You can know more about creb antibodies via www.bosterbio.com/anti-creb-picoband-trade-antibody-pb9100-boster.html.
Although CREB can be found in many tissues, it also plays an important regulatory role in the nervous system. CREB may play a critical role in neuronal survival, precursor proliferation, and neurite outgrowth in certain neuronal populations. In several organisms, CREB signaling also plays a role in memory and learning.
Through interactions with various dimerization partners, CREB can selectively activate many downstream genes. CREB activation is achieved by phosphorylation of Ser133 via various signaling pathways including Erk, Ca 2+ and stress signaling. p90RSK and MSK are some of the kinases that phosphorylate CREB at Ser133.
CREB proteins are activated by phosphorylation from various kinases, including PKA, and Ca2+/calmodulin-dependent protein kinases on the Serine 133 residue. When activated, CREB protein recruits other transcriptional coactivators to bind to CRE promoter 5' upstream region. The inner edge of the alpha-helix contains hydrophobic leucine amino acids.