Various industries rely on effective capsule filling options to create cost-effective products such as vitamins, dietary supplements and pharmaceuticals. Although in theory it appears relatively straightforward, capsule filling is complex and measurements must be accurate to ensure that the product is safe within the prescribed dosage level.
This process should also be easy to repeat to ensure that each capsule is filled individually by default. You can also browse online to find out about the best capsule filling machine supplier in US.
There are many factors to consider in capsule filling operations. This blog discusses capsule filling considerations that are important for medicine, nutrition, and other uses.
Most formulations can be encapsulated in several forms using hard capsules, granules, coated mixtures or pellets. Other common oral dosing methods include tablets and microtablets, and smaller capsules. Many products come in a variety of forms to give to medical providers or consumer choice.
There are some limitations when filling capsules. As an example:
- Mixtures containing reactive aldehydes are not suitable for filling capsules. The reactive aldehyde reacts with a gelatin capsule material called crosslinking, which can cause the encapsulated material to be released more slowly than expected.
- When filling capsules, solids with insufficient flow properties are difficult to control during the filling process. This can result in an inadequate or too full capsule of the wrong weight, which must then be discarded.
- Low viscosity fluids tend to leak out of the two-part capsule immediately after filling, which can affect capsule dosage.
- Hygroscopic fluids absorb additional moisture. Thus, the capsules absorb moisture from the capsule material, making them brittle and brittle.